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KMID : 0882420070720030281
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Korean Journal of Medicine
2007 Volume.72 No. 3 p.281 ~ p.289
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Serum gamma-glutamyl transferase activity has no prognostic value in patients with acute myocardial infarction.
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Lee Jang-Hoon
Chae Shung-Chul
Lee Hyun-Sang
Park Yong-Whi
Ryu Hyeon-Min
Lee Soon-Hak
Bae Myung-Hwan
Yang Dong-Heon
Park Hun-Sik
Cho Yong-Keun
Jun Jae-Eun
Park Wee-Hyun
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Abstract
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Background: Serum gamma-glutamyl transferase activity (GGT) is able to catalyse low-density lipoprotein oxidation in coronary atherosclerotic plaques and has a role in the pathogenesis of atherosclerosis. GGT has been shown to be an independent risk factor for cardiac mortality in patients with a previous myocardial infarction. The purpose of this study is to determine the prognostic value of GGT within its normal range at an acute stage in patients with acute myocardial infarction.
Methods: In a retrospective study, GGT and other cardiac risk factors were evaluated in 192 patients (M/F=143/49; mean age: 60.8+/-11.8 years) who were diagnosed with an acute myocardial infarction at the emergency room. We compared the serum GGT values for each patient with or without a cardiac event, including cardiac death, non-fetal myocardial infarction and unstable angina, after an acute myocardial infarction for a mean follow-up of 16.5+/-10.8 months.
Results: During the follow-up period, 17 patients underwent cardiac death and experienced an acute myocardial infarction and 23 patients had unstable angina. Although the mean GGT values were significantly different from patients with cardiac events (29.5+/-10.0 U/L vs 25.0+/-11.2 U/L, p=0.024), serum GGT was not an independent cardiac risk factor for a cardiac event based on multivariate analysis adjusted for age, sex, alcohol and known cardiovascular risk factors.
Conclusion: Serum GGT within its normal range at an acute stage in patients that experienced an acute myocardial infarction is not an independent prognostic marker.
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KEYWORD
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Gamma-glutamyl transferase, Risk factors, Acute myocardial infarction
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